Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 38 Reviews
8.1
Supplement Facts
Serving Size: 3 capsules
Amount Per Serving
%DV
Organic Milk Thistle seed (Silybum marianum)
1260 mg
†
Organic Milk Thistle seed powdered extract (Silybum marianum) standardized to 80% silymarin
240 mg
†
Top Medical Research Studies
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Read More
8
Silymarin showed enhanced liver protection
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
Read More
Most Useful Reviews
9
Supports liver function
24 people found this helpful
Milk thistle is a great aid for your liver. It traditionally supports liver health, containing thistle seeds and silymarin (80%), a flavonoid complex that protects the liver from toxins. Silymarin promotes the regeneration of liver cells and increases glutathione production, essential for detoxification. I found it beneficial while undertaking serious detoxification protocols. I recommend it!
Read More
10
Life-changing liver support
8 people found this helpful
This Milk Thistle supplement has positively transformed my life after struggling with fatty liver disease for nearly a decade. I felt immediate improvements, making daily life much more manageable. I absolutely love this product!
Read More
9
Healing properties noted
4 people found this helpful
Very healing for the liver! I got positive results from this milk thistle product, known for its organic quality. It has truly helped with my liver health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
9
Silymarin improves liver health in mice
We investigated how silymarin, along with other natural compounds, affects non-alcoholic fatty liver disease (NAFLD) in mice. Over 16 weeks, mice on a high-fat diet received silymarin supplements, which significantly improved liver health and reduced fat buildup.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Read More
9
We investigated the potential of a specially formulated version of Silybum marianum, known as nano-SM, to combat liver damage caused by a compound called 17α-ethinylestradiol (EE).
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
Read More
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Read More
8
Silybum marianum aids liver health
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 38 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports liver function
24 people found this helpful
Milk thistle is a great aid for your liver. It traditionally supports liver health, containing thistle seeds and silymarin (80%), a flavonoid complex that protects the liver from toxins. Silymarin promotes the regeneration of liver cells and increases glutathione production, essential for detoxification. I found it beneficial while undertaking serious detoxification protocols. I recommend it!
Read More
10
Life-changing liver support
8 people found this helpful
This Milk Thistle supplement has positively transformed my life after struggling with fatty liver disease for nearly a decade. I felt immediate improvements, making daily life much more manageable. I absolutely love this product!
Read More
9
Healing properties noted
4 people found this helpful
Very healing for the liver! I got positive results from this milk thistle product, known for its organic quality. It has truly helped with my liver health.
Read More
9
Normal liver tests
3 people found this helpful
Love this product; it comes in a glass bottle, which I believe is a plus (no plastic contamination). The capsules are small and easy to swallow, with a good strength of 420mg per capsule and standardised 80% silymarin, the most beneficial ingredient. Best of all, there are no fillers. I gave it to my dog who had elevated liver enzymes, and after a couple of months, his test results came back normal. I recommend this product for anyone with liver or digestive issues; it's also a great liver detoxifier.
Read More
9
Traditional remedy
3 people found this helpful
Must have for the liver! This remedy is recognised by traditional medicine for any liver problems. The beneficial effect of milk thistle on the liver is due to silymarin—a powerful hepatoprotector, composed of flavonoids and flavolignans. Silymarin is the only natural compound that effectively protects hepatocytes and restores liver function.
Read More
Frequently Asked Questions
9
Improved liver function
1 people found this helpful
Oregon's Wild Harvest Milk Thistle effectively supports liver health, due to its hepatoprotective properties attributed to silymarin. After several months of use, I've noticed significant improvements in my liver function and overall vitality. This supplement has a safe track record, making it a reliable choice for liver support.
9
Instant relief
1 people found this helpful
An excellent remedy for the liver! This high-quality product makes you feel lighter within an hour. It's a reliable hangover cure; just take one pill in the morning after a night out, and you'll feel great the next day!
7.5
Effective detoxification
14 people found this helpful
Excellent for cleansing the liver from toxins, and I found that it lasts for three months for optimal results. Everyone praises it, saying it works wonderfully for liver support. Please remember to like my words and return for my update after three months.
9
Fatty liver improvement
1 people found this helpful
It genuinely works! My husband's fatty liver has improved, and I am using this product as well, hoping for the same success with my fatty liver.
9
Effective protection
2 people found this helpful
I have been taking this excellent product for over a year, and it's effective for liver protection. I always take it after heavy meals or drinking sessions, and I find it quite good. The organic ingredient feels safer compared to other brands, and I hope the price remains stable, or I may have to consider other options.
9
Improved lab values
2 people found this helpful
Daily, I combine Milk Thistle and Artichoke for liver health from Oregon's Wild Harvest. It smells fresh and has helped reduce fatty liver symptoms. Over time, the size of my liver has decreased and even my doctor has noticed! Additionally, my lab values have improved!
9
Supports liver function
24 people found this helpful
Milk thistle is a great aid for your liver. It traditionally supports liver health, containing thistle seeds and silymarin (80%), a flavonoid complex that protects the liver from toxins. Silymarin promotes the regeneration of liver cells and increases glutathione production, essential for detoxification. I found it beneficial while undertaking serious detoxification protocols. I recommend it!
9
Normal liver tests
3 people found this helpful
Love this product; it comes in a glass bottle, which I believe is a plus (no plastic contamination). The capsules are small and easy to swallow, with a good strength of 420mg per capsule and standardised 80% silymarin, the most beneficial ingredient. Best of all, there are no fillers. I gave it to my dog who had elevated liver enzymes, and after a couple of months, his test results came back normal. I recommend this product for anyone with liver or digestive issues; it's also a great liver detoxifier.
7.5
Protects during treatments
1 people found this helpful
I administered this to our father during his chemotherapy. It had the best effects in protecting the liver from high doses of conventional medications. It's not for short-term use; consistent consumption over several weeks is needed to observe benefits.
8
We explored the role of silymarin, a compound from milk thistle, as an antioxidant treatment for chronic liver diseases like hepatitis and cirrhosis. Through a thorough review of clinical studies, we found that silymarin shows promise for protecting the liver and may help improve liver function in patients with these conditions.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
8
Silybum marianum aids liver health
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
8
Silymarin showed enhanced liver protection
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
References
- Koeberle SC, Thürmer M, Su F, Werner M, Grander J, et al. Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids. Theranostics. 2025;15:2006. 10.7150/thno.99562
- Cano Contreras AD, Del Rocío Francisco M, Vargas Basurto JL, Gonzalez-Gomez KD, Amieva-Balmori M, et al. Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17:101704. 10.4254/wjh.v17.i1.101704
- Shaker MK, Hassany M, Eysa B, Adel A, Zidan A, et al. The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepatitis: a phase II, multicentered, randomized, double-blind, placebo-controlled clinical trial. BMC Complement Med Ther. 2025;25:8. 10.1186/s12906-024-04692-y
- Selc M, Macova R, Babelova A. Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders. Drug Des Devel Ther. 2024;18:4629. 10.2147/DDDT.S483140
- Faryadi S, Sheikhahmadi A, Farhadi A, Nourbakhsh H. Evaluating the therapeutic effect of different forms of silymarin on liver status and expression of some genes involved in fat metabolism, antioxidants and anti-inflammatory in older laying hens. Vet Med Sci. 2024;10:e70025. 10.1002/vms3.70025
- Dhande D, Dhok A, Anjankar A, Nagpure S. Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review. Cureus. 2024;16:e67083. 10.7759/cureus.67083
- Li BY, Xi Y, Liu YP, Wang D, Wang C, et al. Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial. Clin Nutr ESPEN. 2024;63:2. 10.1016/j.clnesp.2024.06.003
- Jaffar HM, Al-Asmari F, Khan FA, Rahim MA, Zongo E. Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases-A comprehensive narrative review. Food Sci Nutr. 2024;12:3097. 10.1002/fsn3.4010
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16040520
- Wang X, Jin Y, Di C, Zeng Y, Zhou Y, et al. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024;16. 10.3390/nu16081169
- Salem MB, Mohammed DM, Hammam OA, Elzallat M. Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L. BMC Complement Med Ther. 2024;24:51. 10.1186/s12906-024-04351-2
- Singla RK, Singh D, Verma R, Kaushik D, Echeverría J, et al. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine. 2024;124:155286. 10.1016/j.phymed.2023.155286
- Calderon Martinez E, Herrera D, Mogan S, Hameed Z, Jangda AA, et al. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review. Cureus. 2023;15:e47608. 10.7759/cureus.47608
- Ma X, Yu X, Li R, Cui J, Yu H, et al. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. J Ethnopharmacol. 2024;319:117238. 10.1016/j.jep.2023.117238
- Talebi A, Soltani R, Khorvash F, Jouabadi SM. The Effectiveness of Silymarin in the Prevention of Anti-tuberculosis Drug-induced Hepatotoxicity: A Randomized Controlled Clinical Trial. Int J Prev Med. 2023;14:48. 10.4103/ijpvm.ijpvm_81_22
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. 10.1007/s00228-022-03434-8
